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18 June 2009

Electron microscope


The invention: 

A device for viewing extremely small objects that
uses electron beams and “electron lenses” instead of the light
rays and optical lenses used by ordinary microscopes.

The people behind the invention:

Ernst Ruska (1906-1988), a German engineer, researcher, and
inventor who shared the 1986 Nobel Prize in Physics
Hans Busch (1884-1973), a German physicist
Max Knoll (1897-1969), a German engineer and professor
Louis de Broglie (1892-1987), a French physicist who won the
1929 Nobel Prize in Physics


14 June 2009

Electroencephalogram

The invention: A system of electrodes that measures brain wave patterns in humans, making possible a new era of neurophysiology. The people behind the invention: Hans Berger (1873-1941), a German psychiatrist and research scientist Richard Caton (1842-1926), an English physiologist and surgeon The Electrical Activity of the Brain Hans Berger’s search for the human electroencephalograph (English physiologist Richard Caton had described the electroencephalogram, or “brain wave,” in rabbits and monkeys in 1875) was motivated by his desire to find a physiological method that might be applied successfully to the study of the long-standing problem of the relationship between the mind and the brain. His scientific career, therefore, was directed toward revealing the psychophysical relationship in terms of principles that would be rooted firmly in the natural sciences and would not have to rely upon vague philosophical or mystical ideas. During his early career, Berger attempted to study psychophysical relationships by making plethysmographic measurements of changes in the brain circulation of patients with skull defects. In plethysmography, an instrument is used to indicate and record by tracings the variations in size of an organ or part of the body. Later, Berger investigated temperature changes occurring in the human brain during mental activity and the action of psychoactive drugs. He became disillusioned, however, by the lack of psychophysical understanding generated by these investigations. Next, Berger turned to the study of the electrical activity of the brain, and in the 1920’s he set out to search for the human electroencephalogram. He believed that the electroencephalogram would finally provide him with a physiological method capable of furnishing insight into mental functions and their disturbances.Berger made his first unsuccessful attempt at recording the electrical activity of the brain in 1920, using the scalp of a bald medical student. He then attempted to stimulate the cortex of patients with skull defects by using a set of electrodes to apply an electrical current to the skin covering the defect. The main purpose of these stimulation experiments was to elicit subjective sensations. Berger hoped that eliciting these sensations might give him some clue about the nature of the relationship between the physiochemical events produced by the electrical stimulus and the mental processes revealed by the patients’ subjective experience. The availability of many patients with skull defects—in whom the pulsating surface of the brain was separated from the stimulating electrodes by only a few millimeters of tissue—reactivated Berger’s interest in recording the brain’s electrical activity.Small, Tremulous Movements Berger used several different instruments in trying to detect brain waves, but all of them used a similar method of recording. Electrical oscillations deflected a mirror upon which a light beam was projected. The deflections of the light beam were proportional to the magnitude of the electrical signals. The movement of the spot of the light beam was recorded on photographic paper moving at a speed no greater than 3 centimeters per second. In July, 1924, Berger observed small, tremulous movements of the instrument while recording from the skin overlying a bone defect in a seventeen-year-old patient. In his first paper on the electroencephalogram, Berger described this case briefly as his first successful recording of an electroencephalogram. At the time of these early studies, Berger already had used the term “electroencephalogram” in his diary. Yet for several years he had doubts about the origin of the electrical signals he recorded. As late as 1928, he almost abandoned his electrical recording studies. The publication of Berger’s first paper on the human encephalogram in 1929 had little impact on the scientific world. It was either ignored or regarded with open disbelief. At this time, even when Berger himself was not completely free of doubts about the validity of his findings, he managed to continue his work. He published additional contributions to the study of the electroencephalogram in a series of fourteen papers. As his research progressed, Berger became increasingly confident and convinced of the significance of his discovery. Impact The long-range impact of Berger’s work is incontestable. When Berger published his last paper on the human encephalogram in 1938, the new approach to the study of brain function that he inaugurated in 1929 had gathered momentum in many centers, both in Europe and in the United States. As a result of his pioneering work, a new diagnostic method had been introduced into medicine. Physiology had acquired a new investigative tool. Clinical neurophysiology had been liberated from its dependence upon the functional anatomical approach, and electrophysiological exploration of complex functions of the central nervous system had begun in earnest. Berger’s work had finally received its well-deserved recognition. Many of those who undertook the study of the electroencephalogram were able to bring a far greater technical knowledge of neurophysiology to bear upon the problems of the electrical activity of the brain. Yet the community of neurological scientists has not ceased to look with respect to the founder of electroencephalography, who, despite overwhelming odds and isolation, opened a new area of neurophysiology.

Electrocardiogram

The invention: Device for analyzing the electrical currents of the human heart. The people behind the invention: Willem Einthoven (1860-1927), a Dutch physiologist and winner of the 1924 Nobel Prize in Physiology or Medicine Augustus D. Waller (1856-1922), a German physician and researcher Sir Thomas Lewis (1881-1945), an English physiologist Horse Vibrations In the late 1800’s, there was substantial research interest in the electrical activity that took place in the human body. Researchers studied many organs and systems in the body, including the nerves, eyes, lungs, muscles, and heart. Because of a lack of available technology, this research was tedious and frequently inaccurate. Therefore, the development of the appropriate instrumentation was as important as the research itself. The initial work on the electrical activity of the heart (detected from the surface of the body) was conducted by Augustus D.Waller and published in 1887. Many credit him with the development of the first electrocardiogram. Waller used a Lippmann’s capillary electrometer (named for its inventor, the French physicist Gabriel- Jonas Lippmann) to determine the electrical charges in the heart and called his recording a “cardiograph.” The recording was made by placing a series of small tubes on the surface of the body. The tubes contained mercury and sulfuric acid. As an electrical current passed through the tubes, the mercury would expand and contract. The resulting images were projected onto photographic paper to produce the first cardiograph. Yet Waller had only limited sucess with the device and eventually abandoned it. In the early 1890’s,Willem Einthoven, who became a good friend of Waller, began using the same type of capillary tube to study the electrical currents of the heart. Einthoven also had a difficult time working with the instrument. His laboratory was located in an old wooden building near a cobblestone street. Teams of horses pulling heavy wagons would pass by and cause his laboratory to vibrate. This vibration affected the capillary tube, causing the cardiograph to be unclear. In his frustration, Einthoven began to modify his laboratory. He removed the floorboards and dug a hole some ten to fifteen feet deep. He lined the walls with large rocks to stabilize his instrument. When this failed to solve the problem, Einthoven, too, abandoned the Lippmann’s capillary tube. Yet Einthoven did not abandon the idea, and he began to experiment with other instruments. Electrocardiographs over the Phone In order to continue his research on the electrical currents of the heart, Einthoven began to work with a new device, the d’Arsonval galvanometer (named for its inventor, the French biophysicist Arsène d’Arsonval). This instrument had a heavy coil of wire suspended between the poles of a horseshoe magnet. Changes in electrical activity would cause the coil to move; however, Einthoven found that the coil was too heavy to record the small electrical changes found in the heart. Therefore, he modified the instrument by replacing the coil with a silver-coated quartz thread (string). The movements could be recorded by transmitting the deflections through a microscope and projecting them on photographic film. Einthoven called the new instrument the “string galvanometer.” In developing his string galvanomter, Einthoven was influenced by the work of one of his teachers, Johannes Bosscha. In the 1850’s, Bosscha had published a study describing the technical complexities of measuring very small amounts of electricity. He proposed the idea that a galvanometer modified with a needle hanging from a silk thread would be more sensitive in measuring the tiny electric currents of the heart. By 1905, Einthoven had improved the string galvanometer to the point that he could begin using it for clinical studies. In 1906, he had his laboratory connected to the hospital in Leiden by a telephone wire.With this arrangement, Einthoven was able to study in his laboratory electrocardiograms derived from patients in the hospital, which was located a mile away. With this source of subjects, Einthoven was able to use his galvanometer to study many heart problems. As a result of these studies, Einthoven identified the following heart problems: blocks in the electrical conduction system of the heart; premature beats of the heart, including two premature beats in a row; and enlargements of the various chambers of the heart. He was also able to study how the heart behaved during the administration of cardiac drugs.A major researcher who communicated with Einthoven about the electrocardiogram was Sir Thomas Lewis, who is credited with developing the electrocardiogram into a useful clinical tool. One of Lewis’s important accomplishments was his identification of atrial fibrillation, the overactive state of the upper chambers of the heart. During World War I, Lewis was involved with studying soldiers’ hearts. He designed a series of graded exercises, which he used to test the soldiers’ ability to perform work. From this study, Lewis was able to use similar tests to diagnose heart disease and to screen recruits who had heart problems. Impact As Einthoven published additional studies on the string galvanometer in 1903, 1906, and 1908, greater interest in his instrument was generated around the world. In 1910, the instrument, now called the “electrocardiograph,” was installed in the United States. It was the foundation of a new laboratory for the study of heart disease at Johns Hopkins University. As time passed, the use of the electrocardiogram—or “EKG,” as it is familiarly known—increased substantially. The major advantage of the EKG is that it can be used to diagnose problems in the heart without incisions or the use of needles. It is relatively painless for the patient; in comparison with other diagnostic techniques, moreover, it is relatively inexpensive. Recent developments in the use of the EKG have been in the area of stress testing. Since many heart problems are more evident during exercise, when the heart is working harder, EKGs are often given to patients as they exercise, generally on a treadmill. The clinician gradually increases the intensity of work the patient is doing while monitoring the patient’s heart. The use of stress testing has helped to make the EKG an even more valuable diagnostic tool.

12 June 2009

Electric refrigerator


The invention: 

An electrically powered and hermetically sealed
food-storage appliance that replaced iceboxes, improved production,
and lowered food-storage costs.

The people behind the invention:

Marcel Audiffren, a French monk
Christian Steenstrup (1873-1955), an American engineer
Fred Wolf, an American engineer


Electric clock

The invention: Electrically powered time-keeping device with a quartz resonator that has led to the development of extremely accurate, relatively inexpensive electric clocks that are used in computers and microprocessors. The person behind the invention: Warren Alvin Marrison (1896-1980), an American scientist From Complex Mechanisms to Quartz Crystals William Alvin Marrison’s fabrication of the electric clock began a new era in time-keeping. Electric clocks are more accurate and more reliable than mechanical clocks, since they have fewer moving parts and are less likely to malfunction. An electric clock is a device that generates a string of electric pulses. The most frequently used electric clocks are called “free running” and “periodic,” which means that they generate a continuous sequence of electric pulses that are equally spaced. There are various kinds of electronic “oscillators” (materials that vibrate) that can be used to manufacture electric clocks. The material most commonly used as an oscillator in electric clocks is crystalline quartz. Because quartz (silicon dioxide) is a completely oxidized compound (which means that it does not deteriorate readily) and is virtually insoluble in water, it is chemically stable and resists chemical processes that would break down other materials. Quartz is a “piezoelectric” material, which means that it is capable of generating electricity when it is subjected to pressure or stress of some kind. In addition, quartz has the advantage of generating electricity at a very stable frequency, with little variation. For these reasons, quartz is an ideal material to use as an oscillator.The Quartz Clock Aquartz clock is an electric clock that makes use of the piezoelectric properties of a quartz crystal. When a quartz crystal vibrates, a difference of electric potential is produced between two of its faces. The crystal has a natural frequency (rate) of vibration that is determined by its size and shape. If the crystal is placed in an oscillating electric circuit that has a frequency that is nearly the same as that of the crystal, it will vibrate at its natural frequency and will cause the frequency of the entire circuit to match its own frequency. Piezoelectricity is electricity, or “electric polarity,” that is caused by the application of mechanical pressure on a “dielectric” material (one that does not conduct electricity), such as a quartz crystal. The process also works in reverse; if an electric charge is applied to the dielectric material, the material will experience a mechanical distortion. This reciprocal relationship is called “the piezoelectric effect.” The phenomenon of electricity being generated by the application of mechanical pressure is called the direct piezoelectric effect, and the phenomenon of mechanical stress being produced as a result of the application of electricity is called the converse piezoelectric effect. When a quartz crystal is used to create an oscillator, the natural frequency of the crystal can be used to produce other frequencies that can power clocks. The natural frequency of a quartz crystal is nearly constant if precautions are taken when it is cut and polished and if it is maintained at a nearly constant temperature and pressure. After a quartz crystal has been used for some time, its frequency usually varies slowly as a result of physical changes. If allowances are made for such changes, quartz-crystal clocks such as those used in laboratories can be manufactured that will accumulate errors of only a few thousandths of a second per month. The quartz crystals that are typically used in watches, however, may accumulate errors of tens of seconds per year. There are other materials that can be used to manufacture accurate electric clocks. For example, clocks that use the element rubidium typically would accumulate errors no larger than a few tenthousandths of a second per year, and those that use the element cesium would experience errors of only a few millionths of a second per year. Quartz is much less expensive than rarer materials such as rubidium and cesium, and it is easy to use in such common applications as computers. Thus, despite their relative inaccuracy, electric quartz clocks are extremely useful and popular, particularly for applications that require accurate timekeeping over a relatively short period of time. In such applications, quartz clocks may be adjusted periodically to correct for accumulated errors. Impact The electric quartz clock has contributed significantly to the development of computers and microprocessors. The computer’s control unit controls and synchronizes all data transfers and transformations in the computer system and is the key subsystem in the computer itself. Every action that the computer performs is implemented by the control unit. The computer’s control unit uses inputs from a quartz clock to derive timing and control signals that regulate the actions in the system that are associated with each computer instruction. The control unit also accepts, as input, control signals generated by other devices in the computer system. The other primary impact of the quartz clock is in making the construction of multiphase clocks a simple task. A multiphase clock is a clock that has several outputs that oscillate at the same frequency. These outputs may generate electric waveforms of different shapes or of the same shape, which makes them useful for various applications. It is common for a computer to incorporate a single-phase quartz clock that is used to generate a two-phase clock.

09 June 2009

Dolby noise reduction

The invention: Electronic device that reduces the signal-to-noise ratio of sound recordings and greatly improves the sound quality of recorded music. The people behind the invention: Emil Berliner (1851-1929), a German inventor Ray Milton Dolby (1933- ), an American inventor Thomas Alva Edison (1847-1931), an American inventor Phonographs, Tapes, and Noise Reduction The main use of record, tape, and compact disc players is to listen to music, although they are also used to listen to recorded speeches, messages, and various forms of instruction. Thomas Alva Edison invented the first sound-reproducing machine, which he called the “phonograph,” and patented it in 1877. Ten years later, a practical phonograph (the “gramophone”) was marketed by a German, Emil Berliner. Phonographs recorded sound by using diaphragms that vibrated in response to sound waves and controlled needles that cut grooves representing those vibrations into the first phonograph records, which in Edison’s machine were metal cylinders and in Berliner’s were flat discs. The recordings were then played by reversing the recording process: Placing a needle in the groove in the recorded cylinder or disk caused the diaphragm to vibrate, re-creating the original sound that had been recorded. In the 1920’s, electrical recording methods developed that produced higher-quality recordings, and then, in the 1930’s, stereophonic recording was developed by various companies, including the British company Electrical and Musical Industries (EMI). Almost simultaneously, the technology of tape recording was developed. By the 1940’s, long-playing stereo records and tapes were widely available. As recording techniques improved further, tapes became very popular, and by the 1960’s, they had evolved into both studio master recording tapes and the audio cassettes used by consumers.Hisses and other noises associated with sound recording and its environment greatly diminished the quality of recorded music. In 1967, Ray Dolby invented a noise reducer, later named “Dolby A,” that could be used by recording studios to reduce tape signal-tonoise ratios. Several years later, his “Dolby B” system, designed for home use, became standard equipment in all types of playback machines. Later, Dolby and others designed improved noisesuppression systems. Recording and Tape Noise Sound is made up of vibrations of varying frequencies—sound waves—that sound recorders can convert into grooves on plastic records, varying magnetic arrangements on plastic tapes covered with iron particles, or tiny pits on compact discs. The following discussion will focus on tape recordings, for which the original Dolby noise reducers were designed. Tape recordings are made by a process that converts sound waves into electrical impulses that cause the iron particles in a tape to reorganize themselves into particular magnetic arrangements. The process is reversed when the tape is played back. In this process, the particle arrangements are translated first into electrical impulses and then into sound that is produced by loudspeakers. Erasing a tape causes the iron particles to move back into their original spatial arrangement. Whenever a recording is made, undesired sounds such as hisses, hums, pops, and clicks can mask the nuances of recorded sound, annoying and fatiguing listeners. The first attempts to do away with undesired sounds (noise) involved making tapes, recording devices, and recording studios quieter. Such efforts did not, however, remove all undesired sounds. Furthermore, advances in recording technology increased the problem of noise by producing better instruments that “heard” and transmitted to recordings increased levels of noise. Such noise is often caused by the components of the recording system; tape hiss is an example of such noise. This type of noise is most discernible in quiet passages of recordings, because loud recorded sounds often mask it.Because of the problem of noise in quiet passages of recorded sound, one early attempt at noise suppression involved the reduction of noise levels by using “dynaural” noise suppressors. These devices did not alter the loud portions of a recording; instead, they reduced the very high and very low frequencies in the quiet passages in which noise became most audible. The problem with such devices was, however, that removing the high and low frequencies could also affect the desirable portions of the recorded sound. These suppressors could not distinguish desirable from undesirable sounds. As recording techniques improved, dynaural noise suppressors caused more and more problems, and their use was finally discontinued. Another approach to noise suppression is sound compression during the recording process. This compression is based on the fact that most noise remains at a constant level throughout a recording, regardless of the sound level of a desired signal (such as music). To carry out sound compression, the lowest-level signals in a recording are electronically elevated above the sound level of all noise. Musical nuances can be lost when the process is carried too far, because the maximum sound level is not increased by devices that use sound compression. To return the music or other recorded sound to its normal sound range for listening, devices that “expand” the recorded music on playback are used. Two potential problems associated with the use of sound compression and expansion are the difficulty of matching the two processes and the introduction into the recording of noise created by the compression devices themselves. In 1967, Ray Dolby developed Dolby Ato solve these problems as they related to tape noise (but not to microphone signals) in the recording and playing back of studio master tapes. The system operated by carrying out ten-decibel compression during recording and then restoring (noiselessly) the range of the music on playback. This was accomplished by expanding the sound exactly to its original range. Dolby Awas very expensive and was thus limited to use in recording studios. In the early 1970’s, however, Dolby invented the less expensive Dolby B system, which was intended for consumers. Consequences The development of Dolby Aand Dolby B noise-reduction systems is one of the most important contributions to the high-quality recording and reproduction of sound. For this reason, Dolby A quickly became standard in the recording industry. In similar fashion, Dolby B was soon incorporated into virtually every highfidelity stereo cassette deck to be manufactured. Dolby’s discoveries spurred advances in the field of noise reduction. For example, the German company Telefunken and the Japanese companies Sanyo and Toshiba, among others, developed their own noise-reduction systems. Dolby Laboratories countered by producing an improved system: Dolby C. The competition in the area of noise reduction continues, and it will continue as long as changes in recording technology produce new, more sensitive recording equipment.

Disposable razor

The invention: An inexpensive shaving blade that replaced the traditional straight-edged razor and transformed shaving razors into a frequent household purchase item. The people behind the invention: King Camp Gillette (1855-1932), inventor of the disposable razor Steven Porter, the machinist who created the first three disposable razors for King Camp Gillette William Emery Nickerson (1853-1930), an expert machine inventor who created the machines necessary for mass production Jacob Heilborn, an industrial promoter who helped Gillette start his company and became a partner Edward J. Stewart, a friend and financial backer of Gillette Henry Sachs, an investor in the Gillette Safety Razor Company John Joyce, an investor in the Gillette Safety Razor Company William Painter (1838-1906), an inventor who inspired Gillette George Gillette, an inventor, King Camp Gillette’s father A Neater Way to Shave In 1895, King Camp Gillette thought of the idea of a disposable razor blade. Gillette spent years drawing different models, and finally Steven Porter, a machinist and Gillette’s associate, created from those drawings the first three disposable razors that worked. Gillette soon founded the Gillette Safety Razor Company, which became the leading seller of disposable razor blades in the United States. George Gillette, King Camp Gillette’s father, had been a newspaper editor, a patent agent, and an inventor. He never invented a very successful product, but he loved to experiment. He encouraged all of his sons to figure out how things work and how to improve on them. King was always inventing something new and had many patents, but he was unsuccessful in turning them into profitable businesses. Gillette worked as a traveling salesperson for Crown Cork and Seal Company.William Painter, one of Gillette’s friends and the inventor of the crown cork, presented Gillette with a formula for making a fortune: Invent something that would constantly need to be replaced. Painter’s crown cork was used to cap beer and soda bottles. It was a tin cap covered with cork, used to form a tight seal over a bottle. Soda and beer companies could use a crown cork only once and needed a steady supply. King took Painter’s advice and began thinking of everyday items that needed to be replaced often. After owning a Star safety razor for some time, King realized that the razor blade had not been improved for a long time. He studied all the razors on the market and found that both the common straight razor and the safety razor featured a heavy V-shaped piece of steel, sharpened on one side. King reasoned that a thin piece of steel sharpened on both sides would create a better shave and could be thrown away once it became dull. The idea of the disposable razor had been born. Gillette made several drawings of disposable razors. He then made a wooden model of the razor to better explain his idea. Gillette’s first attempt to construct a working model was unsuccessful, as the steel was too flimsy. Steven Porter, a Boston machinist, decided to try to make Gillette’s razor from his drawings. He produced three razors, and in the summer of 1899 King was the first man to shave with a disposable razor. Changing Consumer Opinion In the early 1900’s, most people considered a razor to be a oncein- a-lifetime purchase. Many fathers handed down their razors to their sons. Straight razors needed constant and careful attention to keep them sharp. The thought of throwing a razor in the garbage after several uses was contrary to the general public’s idea of a razor. If Gillette’s razor had not provided a much less painful and faster shave, it is unlikely that the disposable would have been a success. Even with its advantages, public opinion against the product was still difficult to overcome. Financing a company to produce the razor proved to be a major obstacle. King did not have the money himself, and potential investors were skeptical. Skepticism arose both because of public perceptions of the product and because of its manufacturing process. Mass production appeared to be impossible, but the disposable razor would never be profitable if produced using the methods used to manufacture its predecessor. William Emery Nickerson, an expert machine inventor, had looked at Gillette’s razor and said it was impossible to create a machine to produce it. He was convinced to reexamine the idea and finally created a machine that would create a workable blade. In the process, Nickerson changed Gillette’s original model. He improved the handle and frame so that it would better support the thin steel blade. In the meantime, Gillette was busy getting his patent assigned to the newly formed American Safety Razor Company, owned by Gillette, Jacob Heilborn, Edward J. Stewart, and Nickerson. Gillette owned considerably more shares than anyone else. Henry Sachs provided additional capital, buying shares from Gillette. The stockholders decided to rename the company the Gillette Safety Razor Company. It soon spent most of its money on machinery and lacked the capital it needed to produce and advertise its product. The only offer the company had received was from a group of New York investors who were willing to give $125,000 in exchange for 51 percent of the company. None of the directors wanted to lose control of the company, so they rejected the offer. John Joyce, a friend of Gillette, rescued the financially insecure new company. He agreed to buy $100,000 worth of bonds from the company for sixty cents on the dollar, purchasing the bonds gradually as the company needed money. He also received an equivalent amount of company stock. After an investment of $30,000, Joyce had the option of backing out. This deal enabled the company to start manufacturing and advertising.Impact The company used $18,000 to perfect the machinery to produce the disposable razor blades and razors. Originally the directors wanted to sell each razor with twenty blades for three dollars. Joyce insisted on a price of five dollars. In 1903, five dollars was about one-third of the average American’s weekly salary, and a highquality straight razor could be purchased for about half that price.The other directors were skeptical, but Joyce threatened to buy up all the razors for three dollars and sell them himself for five dollars. Joyce had the financial backing to make this promise good, so the directors agreed to the higher price. The Gillette Safety Razor Company contracted with Townsend& Hunt for exclusive sales. The contract stated that Townsend & Hunt would buy 50,000 razors with twenty blades each during a period of slightly more than a year and would purchase 100,000 sets per year for the following four years. The first advertisement for the product appeared in System Magazine in early fall of 1903, offering the razors by mail order. By the end of 1903, only fifty-one razors had been sold. Since Gillette and most of the directors of the company were not salaried, Gillette had needed to keep his job as salesman with Crown Cork and Seal. At the end of 1903, he received a promotion that meant relocation from Boston to London. Gillette did not want to go and pleaded with the other directors, but they insisted that the company could not afford to put him on salary. The company decided to reduce the number of blades in a set from twenty to twelve in an effort to increase profits without noticeably raising the cost of a set. Gillette resigned the title of company president and left for England. Shortly thereafter, Townsend & Hunt changed its name to the Gillette Sales Company, and three years later the sales company sold out to the parent company for $300,000. Sales of the new type of razor were increasing rapidly in the United States, and Joyce wanted to sell patent rights to European companies for a small percentage of sales. Gillette thought that that would be a horrible mistake and quickly traveled back to Boston. He had two goals: to stop the sale of patent rights, based on his conviction that the foreign market would eventually be very lucrative, and to become salaried by the company. Gillette accomplished both these goals and soon moved back to Boston. Despite the fact that Joyce and Gillette had been good friends for a long time, their business views often differed. Gillette set up a holding company in an effort to gain back controlling interest in the Gillette Safety Razor Company. He borrowed money and convinced his allies in the company to invest in the holding company, eventually regaining control. He was reinstated as president of the company. One clear disagreement was that Gillette wanted to relocate the company to Newark, New Jersey, and Joyce thought that that would be a waste of money. Gillette authorized company funds to be invested in a Newark site. The idea was later dropped, costing the company a large amount of capital. Gillette was not a very wise businessman and made many costly mistakes. Joyce even accused him of deliberately trying to keep the stock price low so that Gillette could purchase more stock. Joyce eventually bought out Gillette, who retained his title as president but had little say about company business. With Gillette out of a management position, the company became more stable and more profitable. The biggest problem the company faced was that it would soon lose its patent rights. After the patent expired, the company would have competition. The company decided that it could either cut prices (and therefore profits) to compete with the lower-priced disposables that would inevitably enter the market, or it could create a new line of even better razors. The company opted for the latter strategy. Weeks before the patent expired, the Gillette Safety Razor Company introduced a new line of razors. Both World War I and World War II were big boosts to the company, which contracted with the government to supply razors to almost all the troops. This transaction created a huge increase in sales and introduced thousands of young men to the Gillette razor. Many of them continued to use Gillettes after returning from the war. Aside from the shaky start of the company, its worst financial difficulties were during the Great Depression. Most Americans simply could not afford Gillette blades, and many used a blade for an extended time and then resharpened it rather than throwing it away. If it had not been for the company’s foreign markets, the company would not have shown a profit during the Great Depression. Gillette’s obstinancy about not selling patent rights to foreign investors proved to be an excellent decision. The company advertised through sponsoring sporting events, including the World Series. Gillette had many celebrity endorsements from well-known baseball players. Before it became too expensive for one company to sponsor an entire event, Gillette had exclusive advertising during the World Series, various boxing matches, the Kentucky Derby, and football bowl games. Sponsoring these events was costly, but sports spectators were the typical Gillette customers. The Gillette Company created many products that complemented razors and blades, including shaving cream, women’s raincluding women’s cosmetics, writing utensils, deodorant, and wigs. One of the main reasons for obtaining a more diverse product line was that a one-product company is less stable, especially in a volatile market. The Gillette Company had learned that lesson in the Great Depression. Gillette continued to thrive by following the principles the company had used from the start. The majority of Gillette’s profits came from foreign markets, and its employees looked to improve products and find opportunities in other departments as well as their own.

Dirigible

The invention: Arigid lighter-than-air aircraft that played a major role in World War I and in international air traffic until a disastrous accident destroyed the industry. The people behind the invention: Ferdinand von Zeppelin (1838-1917), a retired German general Theodor Kober (1865-1930), Zeppelin’s private engineer Early Competition When the Montgolfier brothers launched the first hot-air balloon in 1783, engineers—especially those in France—began working on ways to use machines to control the speed and direction of balloons. They thought of everything: rowing through the air with silk-covered oars; building movable wings; using a rotating fan, an airscrew, or a propeller powered by a steam engine (1852) or an electric motor (1882). At the end of the nineteenth century, the internal combustion engine was invented. It promised higher speeds and more power. Up to this point, however, the balloons were not rigid. Arigid airship could be much larger than a balloon and could fly farther. In 1890, a rigid airship designed by David Schwarz of Dalmatia was tested in St. Petersburg, Russia. The test failed because there were problems with inflating the dirigible. A second test, in Berlin in 1897, was only slightly more successful, since the hull leaked and the flight ended in a crash. Schwarz’s airship was made of an entirely rigid aluminum cylinder. Ferdinand von Zeppelin had a different idea: His design was based on a rigid frame. Zeppelin knew about balloons from having fought in two wars in which they were used: the American Civil War of 1861-1865 and the Franco-Prussian War of 1870-1871. He wrote down his first “thoughts about an airship” in his diary on March 25, 1874, inspired by an article about flying and international mail. Zeppelin soon lost interest in this idea of civilian uses for an airship and concentrated instead on the idea that dirigible balloons might become an important part of modern warfare. He asked the German government to fund his research, pointing out that France had a better military air force than Germany did. Zeppelin’s patriotism was what kept him trying, in spite of money problems and technical difficulties. In 1893, in order to get more money, Zeppelin tried to persuade the German military and engineering experts that his invention was practical. Even though a government committee decided that his work was worth a small amount of funding, the army was not sure that Zeppelin’s dirigible was worth the cost. Finally, the committee chose Schwarz’s design. In 1896, however, Zeppelin won the support of the powerful Union of German Engineers, which in May, 1898, gave him 800,000 marks to form a stock company called the Association for the Promotion of Airship Flights. In 1899, Zeppelin began building his dirigible in Manzell at Lake Constance. In July, 1900, the airship was finished and ready for its first test flight. Several Attempts Zeppelin, together with his engineer, Theodor Kober, had worked on the design since May, 1892, shortly after Zeppelin’s retirement from the army. They had finished the rough draft by 1894, and though they made some changes later, this was the basic design of the Zeppelin. An improved version was patented in December, 1897. In the final prototype, called the LZ 1, the engineers tried to make the airship as light as possible. They used a light internal combustion engine and designed a frame made of the light metal aluminum. The airship was 128 meters long and had a diameter of 11.7 meters when inflated. Twenty-four zinc-aluminum girders ran the length of the ship, being drawn together at each end. Sixteen rings held the body together. The engineers stretched an envelope of smooth cotton over the framework to reduce wind resistance and to protect the gas bags fromthe sun’s rays. Seventeen gas bags made of rubberized cloth were placed inside the framework. Together they held more than 120,000 cubic meters of hydrogen gas, which would lift 11,090 kilograms. Two motor gondolas were attached to the sides, each with a 16-horsepower gasoline engine, spinning four propellers.The test flight did not go well. The two main questions—whether the craft was strong enough and fast enough—could not be answered because little things kept going wrong; for example, a crankshaft broke and a rudder jammed. The first flight lasted no more than eighteen minutes, with a maximum speed of 13.7 kilometers per hour. During all three test flights, the airship was in the air for a total of only two hours, going no faster than 28.2 kilometers per hour. Zeppelin had to drop the project for some years because he ran out of money, and his company was dissolved. The LZ 1 was wrecked in the spring of 1901. A second airship was tested in November, 1905, and January, 1906. Both tests were unsuccessful, and in the end the ship was destroyed during a storm. By 1906, however, the German government was convinced of the military usefulness of the airship, though it would not give money to Zeppelin unless he agreed to design one that could stay in the air for at least twenty-four hours. The third Zeppelin failed this test in the autumn of 1907. Finally, in the summer of 1908, the LZ 4 not only proved itself to the military but also attracted great publicity. It flew for more than twenty-four hours and reached a speed of more than 60 kilometers per hour. Caught in a storm at the end of this flight, the airship was forced to land and exploded, but money came from all over Germany to build another. Impact Most rigid airships were designed and flown in Germany. Of the 161 that were built between 1900 and 1938, 139 were made in Germany, and 119 were based on the Zeppelin design. More than 80 percent of the airships were built for the military. The Germans used more than one hundred for gathering information and for bombing during World War I (1914-1918). Starting in May, 1915, airships bombed Warsaw, Poland; Bucharest, Romania; Salonika, Greece; and London, England. This was mostly a fear tactic, since the attacks did not cause great damage, and the English antiaircraft defense improved quickly. By 1916, the German army had lost so many airships that it stopped using them, though the navy continued. Airships were first used for passenger flights in 1910. By 1914, the Delag (German Aeronautic Stock Company) used seven passenger airships for sightseeing trips around German cities. There were still problems with engine power and weather forecasting, and it was difficult to move the airships on the ground. AfterWorldWar I, the Zeppelins that were left were given to the Allies as payment, and the Germans were not allowed to build airships for their own use until 1925. In the 1920’s and 1930’s, it became cheaper to use airplanes for short flights, so airships were useful mostly for long-distance flight. ABritish airship made the first transatlantic flight in 1919. The British hoped to connect their empire by means of airships starting in 1924, but the 1930 crash of the R-101, in which most of the leading English aeronauts were killed, brought that hope to an end. The United States Navy built the Akron (1931) and the Macon (1933) for long-range naval reconnaissance, but both airships crashed. Only the Germans continued to use airships on a regular basis. In 1929, the world tour of the Graf Zeppelin was a success. Regular flights between Germany and South America started in 1932, and in 1936, German airships bearing Nazi swastikas flew to Lakehurst, New Jersey. The tragic explosion of the hydrogen-filled Hindenburg in 1937, however, brought the era of the rigid airship to a close. The U.S. secretary of the interior vetoed the sale of nonflammable helium, fearing that the Nazis would use it for military purposes, and the German government had to stop transatlantic flights for safety reasons. In 1940, the last two remaining rigid airships were destroyed.

Differential analyzer

The invention: An electromechanical device capable of solving differential equations. The people behind the invention: Vannevar Bush (1890-1974), an American electrical engineer Harold L. Hazen (1901-1980), an American electrical engineer Electrical Engineering Problems Become More Complex AfterWorldWar I, electrical engineers encountered increasingly difficult differential equations as they worked on vacuum-tube circuitry, telephone lines, and, particularly, long-distance power transmission lines. These calculations were lengthy and tedious. Two of the many steps required to solve them were to draw a graph manually and then to determine the area under the curve (essentially, accomplishing the mathematical procedure called integration). In 1925, Vannevar Bush, a faculty member in the Electrical Engineering Department at the Massachusetts Institute of Technology (MIT), suggested that one of his graduate students devise a machine to determine the area under the curve. They first considered a mechanical device but later decided to seek an electrical solution. Realizing that a watt-hour meter such as that used to measure electricity in most homes was very similar to the device they needed, Bush and his student refined the meter and linked it to a pen that automatically recorded the curve. They called this machine the Product Integraph, and MIT students began using it immediately. In 1927, Harold L. Hazen, another MIT faculty member, modified it in order to solve the more complex second-order differential equations (it originally solved only firstorder equations). The Differential Analyzer The original Product Integraph had solved problems electrically, and Hazen’s modification had added a mechanical integrator. Although the revised Product Integraph was useful in solving the types of problems mentioned above, Bush thought the machine could be improved by making it an entirely mechanical integrator, rather than a hybrid electrical and mechanical device. In late 1928, Bush received funding from MIT to develop an entirely mechanical integrator, and he completed the resulting Differential Analyzer in 1930. This machine consisted of numerous interconnected shafts on a long, tablelike framework, with drawing boards flanking one side and six wheel-and-disk integrators on the other. Some of the drawing boards were configured to allow an operator to trace a curve with a pen that was linked to the Analyzer, thus providing input to the machine. The other drawing boards were configured to receive output from the Analyzer via a pen that drew a curve on paper fastened to the drawing board. The wheel-and-disk integrator, which Hazen had first used in the revised Product Integraph, was the key to the operation of the Differential Analyzer. The rotational speed of the horizontal disk was the input to the integrator, and it represented one of the variables in the equation. The smaller wheel rolled on the top surface of the disk, and its speed, which was different from that of the disk, represented the integrator’s output. The distance from the wheel to the center of the disk could be changed to accommodate the equation being solved, and the resulting geometry caused the two shafts to turn so that the output was the integral of the input. The integrators were linked mechanically to other devices that could add, subtract, multiply, and divide. Thus, the Differential Analyzer could solve complex equations involving many different mathematical operations. Because all the linkages and calculating devices were mechanical, the Differential Analyzer actually acted out each calculation. Computers of this type, which create an analogy to the physical world, are called analog computers. The Differential Analyzer fulfilled Bush’s expectations, and students and researchers found it very useful. Although each different problem required Bush’s team to set up a new series of mechanical linkages, the researchers using the calculations viewed this as a minor inconvenience. Students at MIT used the Differential Analyzer in research for doctoral dissertations, master’s theses, and bachelor’s theses. Other researchers worked on a wide range of problems with the Differential Analyzer, mostly in electrical engineering, but also in atomic physics, astrophysics, and seismology. An English researcher, Douglas Hartree, visited Bush’s laboratory in 1933 to learn about the Differential Analyzer and to use it in his own work on the atomic field of mercury. When he returned to England, he built several analyzers based on his knowledge of MIT’s machine. The U.S. Army also built a copy in order to carry out the complex calculations required to create artillery firing tables (which specified the proper barrel angle to achieve the desired range). Other analyzers were built by industry and universities around the world. Impact As successful as the Differential Analyzer had been, Bush wanted to make another, better analyzer that would be more precise, more convenient to use, and more mathematically flexible. In 1932, Bush began seeking money for his new machine, but because of the Depression it was not until 1936 that he received adequate funding for the Rockefeller Analyzer, as it came to be known. Bush left MIT in 1938, but work on the Rockefeller Analyzer continued. It was first demonstrated in 1941, and by 1942, it was being used in the war effort to calculate firing tables and design radar antenna profiles. At the end of the war, it was the most important computer in existence. All the analyzers, which were mechanical computers, faced serious limitations in speed because of the momentum of the machinery, and in precision because of slippage and wear. The digital computers that were being developed after World War II (even at MIT) were faster, more precise, and capable of executing more powerful operations because they were electrical computers. As a result, during the 1950’s, they eclipsed differential analyzers such as those built by Bush. Descendants of the Differential Analyzer remained in use as late as the 1990’s, but they played only a minor role.

Diesel locomotive

The invention: An internal combustion engine in which ignition is achieved by the use of high-temperature compressed air, rather than a spark plug. The people behind the invention: Rudolf Diesel (1858-1913), a German engineer and inventor Sir Dugold Clark (1854-1932), a British engineer Gottlieb Daimler (1834-1900), a German engineer Henry Ford (1863-1947), an American automobile magnate Nikolaus Otto (1832-1891), a German engineer and Daimler’s teacher A Beginning in Winterthur By the beginning of the twentieth century, new means of providing society with power were needed. The steam engines that were used to run factories and railways were no longer sufficient, since they were too heavy and inefficient. At that time, Rudolf Diesel, a German mechanical engineer, invented a new engine. His diesel engine was much more efficient than previous power sources. It also appeared that it would be able to run on a wide variety of fuels, ranging fromoil to coal dust. Diesel first showed that his engine was practical by building a diesel-driven locomotive that was tested in 1912. In the 1912 test runs, the first diesel-powered locomotive was operated on the track of the Winterthur-Romanston rail line in Switzerland. The locomotive was built by a German company, Gesellschaft für Thermo-Lokomotiven, which was owned by Diesel and his colleagues. Immediately after the test runs atWinterthur proved its efficiency, the locomotive—which had been designed to pull express trains on Germany’s Berlin-Magdeburg rail line—was moved to Berlin and put into service. It worked so well that many additional diesel locomotives were built. In time, diesel engines were also widely used to power many other machines, including those that ran factories, motor vehicles, and ships.Diesels, Diesels Everywhere In the 1890’s, the best engines available were steam engines that were able to convert only 5 to 10 percent of input heat energy to useful work. The burgeoning industrial society and a widespread network of railroads needed better, more efficient engines to help businesses make profits and to speed up the rate of transportation available for moving both goods and people, since the maximum speed was only about 48 kilometers per hour. In 1894, Rudolf Diesel, then thirty-five years old, appeared in Augsburg, Germany, with a new engine that he believed would demonstrate great efficiency. The diesel engine demonstrated at Augsburg ran for only a short time. It was, however, more efficient than other existing engines. In addition, Diesel predicted that his engines would move trains faster than could be done by existing engines and that they would run on a wide variety of fuels. Experimentation proved the truth of his claims; even the first working motive diesel engine (the one used in the Winterthur test) was capable of pulling heavy freight and passenger trains at maximum speeds of up to 160 kilometers per hour. By 1912, Diesel, a millionaire, saw the wide use of diesel locomotives in Europe and the United States and the conversion of hundreds of ships to diesel power. Rudolf Diesel’s role in the story ends here, a result of his mysterious death in 1913—believed to be a suicide by the authorities—while crossing the English Channel on the steamer Dresden. Others involved in the continuing saga of diesel engines were the Britisher Sir Dugold Clerk, who improved diesel design, and the American Adolphus Busch (of beer-brewing fame), who bought the North American rights to the diesel engine. The diesel engine is related to automobile engines invented by Nikolaus Otto and Gottlieb Daimler. The standard Otto-Daimler (or Otto) engine was first widely commercialized by American auto magnate Henry Ford. The diesel and Otto engines are internalcombustion engines. This means that they do work when a fuel is burned and causes a piston to move in a tight-fitting cylinder. In diesel engines, unlike Otto engines, the fuel is not ignited by a spark from a spark plug. Instead, ignition is accomplished by the use of high-temperature compressed air.In common “two-stroke” diesel engines, pioneered by Sir Dugold Clerk, a starter causes the engine to make its first stroke. This draws in air and compresses the air sufficiently to raise its temperature to 900 to 1,000 degrees Fahrenheit. At this point, fuel (usually oil) is sprayed into the cylinder, ignites, and causes the piston to make its second, power-producing stroke. At the end of that stroke, more air enters as waste gases leave the cylinder; air compression occurs again; and the power-producing stroke repeats itself. This process then occurs continuously, without restarting. Impact Proof of the functionality of the first diesel locomotive set the stage for the use of diesel engines to power many machines. Although Rudolf Diesel did not live to see it, diesel engines were widely used within fifteen years after his death. At first, their main applications were in locomotives and ships. Then, because diesel engines are more efficient and more powerful than Otto engines, they were modified for use in cars, trucks, and buses. At present, motor vehicle diesel engines are most often used in buses and long-haul trucks. In contrast, diesel engines are not as popular in automobiles as Otto engines, although European auto makers make much wider use of diesel engines than American automakers do. Many enthusiasts, however, view diesel automobiles as the wave of the future. This optimism is based on the durability of the engine, its great power, and the wide range and economical nature of the fuels that can be used to run it. The drawbacks of diesels include the unpleasant odor and high pollutant content of their emissions. Modern diesel engines are widely used in farm and earth-moving equipment, including balers, threshers, harvesters, bulldozers,rock crushers, and road graders. Construction of the Alaskan oil pipeline relied heavily on equipment driven by diesel engines. Diesel engines are also commonly used in sawmills, breweries, coal mines, and electric power plants. Diesel’s brainchild has become a widely used power source, just as he predicted. It is likely that the use of diesel engines will continue and will expand, as the demands of energy conservation require more efficient engines and as moves toward fuel diversification require engines that can be used with various fuels.

06 June 2009

Cyclotron

The invention: The first successful magnetic resonance accelerator for protons, the cyclotron gave rise to the modern era of particle accelerators, which are used by physicists to study the structure of atoms. The people behind the invention: Ernest Orlando Lawrence (1901-1958), an American nuclear physicist who was awarded the 1939 Nobel Prize in Physics M. Stanley Livingston (1905-1986), an American nuclear physicist Niels Edlefsen (1893-1971), an American physicist David Sloan (1905- ), an American physicist and electrical engineer The Beginning of an Era The invention of the cyclotron by Ernest Orlando Lawrence marks the beginning of the modern era of high-energy physics. Although the energies of newer accelerators have increased steadily, the principles incorporated in the cyclotron have been fundamental to succeeding generations of accelerators, many of which were also developed in Lawrence’s laboratory. The care and support for such machines have also given rise to “big science”: the massing of scientists, money, and machines in support of experiments to discover the nature of the atom and its constituents. At the University of California, Lawrence took an interest in the new physics of the atomic nucleus, which had been developed by the British physicist Ernest Rutherford and his followers in England, and which was attracting more attention as the development of quantum mechanics seemed to offer solutions to problems that had long preoccupied physicists. In order to explore the nucleus of the atom, however, suitable probes were required. An artificial means of accelerating ions to high energies was also needed. During the late 1920’s, various means of accelerating alpha particles, protons (hydrogen ions), and electrons had been tried, but none had been successful in causing a nuclear transformation when Lawrence entered the field. The high voltages required exceeded the resources available to physicists. It was believed that more than a million volts would be required to accelerate an ion to sufficient energies to penetrate even the lightest atomic nuclei. At such voltages, insulators broke down, releasing sparks across great distances. European researchers even attempted to harness lightning to accomplish the task, with fatal results. Early in April, 1929, Lawrence discovered an article by a German electrical engineer that described a linear accelerator of ions that worked by passing an ion through two sets of electrodes, each of which carried the same voltage and increased the energy of the ions correspondingly. By spacing the electrodes appropriately and using an alternating electrical field, this “resonance acceleration” of ions could speed subatomic particles to many times the energy applied in each step, overcoming the problems presented when one tried to apply a single charge to an ion all at once. Unfortunately, the spacing of the electrodes would have to be increased as the ions were accelerated, since they would travel farther between each alternation of the phase of the accelerating charge, making an accelerator impractically long in those days of small-scale physics. Fast-Moving Streams of Ions Lawrence knew that a magnetic field would cause the ions to be deflected and form a curved path. If the electrodes were placed across the diameter of the circle formed by the ions’ path, they should spiral out as they were accelerated, staying in phase with the accelerating charge until they reached the periphery of the magnetic field. This, it seemed to him, afforded a means of producing indefinitely high voltages without using high voltages by recycling the accelerated ions through the same electrodes. Many scientists doubted that such a method would be effective. No mechanism was known that would keep the circulating ions in sufficiently tight orbits to avoid collisions with the walls of the accelerating chamber. Others tried unsuccessfully to use resonance acceleration. Agraduate student, M. Stanley Livingston, continued Lawrence’s work. For his dissertation project, he used a brass cylinder 10 centimeters in diameter sealed with wax to hold a vacuum, a half-pillbox of copper mounted on an insulated stem to serve as the electrode, and a Hartley radio frequency oscillator producing 10 watts. The hydrogen molecular ions were produced by a thermionic cathode (mounted near the center of the apparatus) from hydrogen gas admitted through an aperture in the side of the cylinder after a vacuum had been produced by a pump. Once formed, the oscillating electrical field drew out the ions and accelerated them as they passed through the cylinder. The accelerated ions spiraled out in a magnetic field produced by a 10-centimeter electromagnet to a collector. By November, 1930, Livingston had observed peaks in the collector current as he tuned the magnetic field through the value calculated to produce acceleration. Borrowing a stronger magnet and tuning his radio frequency oscillator appropriately, Livingston produced 80,000-electronvolt ions at his collector on January 2, 1931, thus demonstrating the principle of magnetic resonance acceleration.Impact Demonstration of the principle led to the construction of a succession of large cyclotrons, beginning with a 25-centimeter cyclotron developed in the spring and summer of 1931 that produced one-million-electronvolt protons. With the support of the Research Corporation, Lawrence secured a large electromagnet that had been developed for radio transmission and an unused laboratory to house it: the Radiation Laboratory. The 69-centimeter cyclotron built with the magnet was used to explore nuclear physics. It accelerated deuterons, ions of heavy water or deuterium that contain, in addition to the proton, the neutron, which was discovered by Sir James Chadwick in 1932. The accelerated deuteron, which injected neutrons into target atoms, was used to produce a wide variety of artificial radioisotopes. Many of these, such as technetium and carbon 14, were discovered with the cyclotron and were later used in medicine. By 1939, Lawrence had built a 152-centimeter cyclotron for medical applications, including therapy with neutron beams. In that year, he won the Nobel Prize in Physics for the invention of the cyclotron and the production of radioisotopes. During World War II, Lawrence and the members of his Radiation Laboratory developed electromagnetic separation of uranium ions to produce the uranium 235 required for the atomic bomb. After the war, the 467-centimeter cyclotron was completed as a synchrocyclotron, which modulated the frequency of the accelerating fields to compensate for the increasing mass of ions as they approached the speed of light. The principle of synchronous acceleration, invented by Lawrence’s associate, the American physicist Edwin Mattison McMillan, became fundamental to proton and electron synchrotrons. The cyclotron and the Radiation Laboratory were the center of accelerator physics throughout the 1930’s and well into the postwar era. The invention of the cyclotron not only provided a new tool for probing the nucleus but also gave rise to new forms of organizing scientific work and to applications in nuclear medicine and nuclear chemistry. Cyclotrons were built in many laboratories in the United States, Europe, and Japan, and they became a standard tool of nuclear physics.

02 June 2009

Cyclamate

The invention: An artificial sweetener introduced to the American market in 1950 under the tradename Sucaryl. The person behind the invention: Michael Sveda (1912-1999), an American chemist A Foolhardy Experiment The first synthetic sugar substitute, saccharin, was developed in 1879. It became commercially available in 1907 but was banned for safety reasons in 1912. Sugar shortages during World War I (1914- 1918) resulted in its reintroduction. Two other artificial sweeteners, Dulcin and P-4000, were introduced later but were banned in 1950 for causing cancer in laboratory animals. In 1937, Michael Sveda was a young chemist working on his Ph.D. at the University of Illinois. Aflood in the Ohio valley had ruined the local pipe-tobacco crop, and Sveda, a smoker, had been forced to purchase cigarettes. One day while in the laboratory, Sveda happened to brush some loose tobacco from his lips and noticed that his fingers tasted sweet. Having a curious, if rather foolhardy, nature, Sveda tasted the chemicals on his bench to find which one was responsible for the taste. The culprit was the forerunner of cyclohexylsulfamate, the material that came to be known as “cyclamate.” Later, on reviewing his career, Sveda explained the serendipitous discovery with the comment: “God looks after . . . fools, children, and chemists.” Sveda joined E. I. Du Pont de Nemours and Company in 1939 and assigned the patent for cyclamate to his employer. In June of 1950, after a decade of testing on animals and humans, Abbott Laboratories announced that it was launching Sveda’s artificial sweetener under the trade name Sucaryl. Du Pont followed with its sweetener product, Cyclan. A Time magazine article in 1950 announced the new product and noted that Abbott had warned that because the product was a sodium salt, individuals with kidney problems should consult their doctors before adding it to their food.Cyclamate had no calories, but it was thirty to forty times sweeter than sugar. Unlike saccharin, cyclamate left no unpleasant aftertaste. The additive was also found to improve the flavor of some foods, such as meat, and was used extensively to preserve various foods. By 1969, about 250 food products contained cyclamates, including cakes, puddings, canned fruit, ice cream, salad dressings, and its most important use, carbonated beverages. It was originally thought that cyclamates were harmless to the human body. In 1959, the chemical was added to the GRAS (generally recognized as safe) list. Materials on this list, such as sugar, salt, pepper, and vinegar, did not have to be rigorously tested before being added to food. In 1964, however, a report cited evidence that cyclamates and saccharin, taken together, were a health hazard. Its publication alarmed the scientific community. Numerous investigations followed. Shooting Themselves in the Foot Initially, the claims against cyclamate had been that it caused diarrhea or prevented drugs from doing their work in the body. By 1969, these claims had begun to include the threat of cancer. Ironically, the evidence that sealed the fate of the artificial sweetener was provided by Abbott itself. Aprivate Long Island company had been hired by Abbott to conduct an extensive toxicity study to determine the effects of longterm exposure to the cyclamate-saccharin mixtures often found in commercial products. The team of scientists fed rats daily doses of the mixture to study the effect on reproduction, unborn fetuses, and fertility. In each case, the rats were declared to be normal. When the rats were killed at the end of the study, however, those that had been exposed to the higher doses showed evidence of bladder tumors. Abbott shared the report with investigators from the National Cancer Institute and then with the U.S. Food and Drug Administration (FDA). The doses required to produce the tumors were equivalent to an individual drinking 350 bottles of diet cola a day. That was more than one hundred times greater than that consumed even by those people who consumed a high amount of cyclamate. A six-person panel of scientists met to review the data and urged the ban of all cyclamates from foodstuffs. In October, 1969, amid enormous media coverage, the federal government announced that cyclamates were to be withdrawn from the market by the beginning of 1970. In the years following the ban, the controversy continued. Doubt was cast on the results of the independent study linking sweetener use to tumors in rats, because the study was designed not to evaluate cancer risks but to explain the effects of cyclamate use over many years. Bladder parasites, known as “nematodes,” found in the rats may have affected the outcome of the tests. In addition, an impurity found in some of the saccharin used in the study may have led to the problems observed. Extensive investigations such as the three-year project conducted at the National Cancer Research Center in Heidelberg, Germany, found no basis for the widespread ban. In 1972, however, rats fed high doses of saccharin alone were found to have developed bladder tumors. At that time, the sweetener was removed from the GRAS list. An outright ban was averted by the mandatory use of labels alerting consumers that certain products contained saccharin. Impact The introduction of cyclamate heralded the start of a new industry. For individuals who had to restrict their sugar intake for health reasons, or for those who wished to lose weight, there was now an alternative to giving up sweet food. The Pepsi-Cola company put a new diet drink formulation on the market almost as soon as the ban was instituted. In fact, it ran advertisements the day after the ban was announced showing the Diet Pepsi product boldly proclaiming “Sugar added—No Cyclamates.” Sveda, the discoverer of cyclamates, was not impressed with the FDA’s decision on the sweetener and its handling of subsequent investigations. He accused the FDAof “a massive cover-up of elemental blunders” and claimed that the original ban was based on sugar politics and bad science. For the manufacturers of cyclamate, meanwhile, the problem lay with the wording of the Delaney amendment, the legislation that regulates new food additives. The amendment states that the manufacturer must prove that its product is safe, rather than the FDAhaving to prove that it is unsafe. The onus was on Abbott Laboratories to deflect concerns about the safety of the product, and it remained unable to do so.

Cruise missile

The invention: Aircraft weapons system that makes it possible to attack both land and sea targets with extreme accuracy without endangering the lives of the pilots. The person behind the invention: Rear Admiral Walter M. Locke (1930- ), U.S. Navy project manager From the Buzz Bombs of World War II During World War II, Germany developed and used two different types of missiles: ballistic missiles and cruise missiles.Aballistic missile is one that does not use aerodynamic lift in order to fly. It is fired into the air by powerful jet engines and reaches a high altitude; when its engines are out of fuel, it descends on its flight path toward its target. The German V-2 was the first ballistic missile. The United States and other countries subsequently developed a variety of highly sophisticated and accurate ballistic missiles. The other missile used by Germany was a cruise missile called the V-1, which was also called the flying bomb or the buzz bomb. The V-1 used aerodynamic lift in order to fly, just as airplanes do. It flew relatively low and was slow; by the end of the war, the British, against whom it was used, had developed techniques for countering it, primarily by shooting it down. After World War II, both the United States and the Soviet Union carried on the Germans’ development of both ballistic and cruise missiles. The United States discontinued serious work on cruise missile technology during the 1950’s: The development of ballistic missiles of great destructive capability had been very successful. Ballistic missiles armed with nuclear warheads had become the basis for the U.S. strategy of attempting to deter enemy attacks with the threat of a massive missile counterattack. In addition, aircraft carriers provided an air-attack capability similar to that of cruise missiles. Finally, cruise missiles were believed to be too vulnerable to being shot down by enemy aircraft or surface-to-air missiles.While ballistic missiles are excellent for attacking large, fixed targets, they are not suitable for attacking moving targets. They can be very accurately aimed, but since they are not very maneuverable during their final descent, they are limited in their ability to change course to hit a moving target, such as a ship. During the 1967 war, the Egyptians used a Soviet-built cruise missile to sink the Israeli ship Elath. The U.S. military, primarily the Navy and the Air Force, took note of the Egyptian success and within a few years initiated cruise missile development programs. The Development of Cruise Missiles The United States probably could have developed cruise missiles similar to 1990’s models as early as the 1960’s, but it would have required a huge effort. The goal was to develop missiles that could be launched from ships and planes using existing launching equipment, could fly long distances at low altitudes at fairly high speeds, and could reach their targets with a very high degree of accuracy. If the missiles flew too slowly, they would be fairly easy to shoot down, like the German V-1’s. If they flew at too high an altitude, they would be vulnerable to the same type of surface-based missiles that shot down Gary Powers, the pilot of the U.S. U2 spyplane, in 1960. If they were inaccurate, they would be of little use. The early Soviet cruise missiles were designed to meet their performance goals without too much concern about how they would be launched. They were fairly large, and the ships that launched them required major modifications. The U.S. goal of being able to launch using existing equipment, without making major modifications to the ships and planes that would launch them, played a major part in their torpedo-like shape: Sea-Launched Cruise Missiles (SLCMs) had to fit in the submarine’s torpedo tubes, and Air- Launched Cruise Missiles (ALCMs) were constrained to fit in rotary launchers. The size limitation also meant that small, efficient jet engines would be required that could fly the long distances required without needing too great a fuel load. Small, smart computers were needed to provide the required accuracy. The engine and computer technologies began to be available in the 1970’s, and they blossomed in the 1980’s.The U.S. Navy initiated cruise missile development efforts in 1972; the Air Force followed in 1973. In 1977, the Joint Cruise Missile Project was established, with the Navy taking the lead. Rear Admiral Walter M. Locke was named project manager. The goal was to develop air-, sea-, and ground-launched cruise missiles. By coordinating activities, encouraging competition, and requiring the use of common components wherever possible, the cruise missile development program became a model for future weapon-system development efforts. The primary contractors included Boeing Aerospace Company, General Dynamics, and McDonnell Douglas. In 1978, SLCMs were first launched from submarines. Over the next few years, increasingly demanding tests were passed by several versions of cruise missiles. By the mid-1980’s, both antiship and antiland missiles were available. An antiland version could be guided to its target with extreme accuracy by comparing a map programmed into its computer to the picture taken by an on-board video camera. The typical cruise missile is between 18 and 21 feet long, about 21 inches in diameter, and has a wingspan of between 8 and 12 feet. Cruise missiles travel slightly below the speed of sound and have a range of around 1,350 miles (antiland) or 250 miles (antiship). Both conventionally armed and nuclear versions have been fielded. Consequences Cruise missiles have become an important part of the U.S. arsenal. They provide a means of attacking targets on land and water without having to put an aircraft pilot’s life in danger. Their value was demonstrated in 1991 during the Persian GulfWar. One of their uses was to “soften up” defenses prior to sending in aircraft, thus reducing the risk to pilots. Overall estimates are that about 85 percent of cruise missiles used in the Persian Gulf War arrived on target, which is an outstanding record. It is believed that their extreme accuracy also helped to minimize noncombatant casualties.

31 May 2009

Coronary artery bypass surgery

The invention: The most widely used procedure of its type, coronary bypass surgery uses veins from legs to improve circulation to the heart. The people behind the invention: Rene Favaloro (1923-2000), a heart surgeon Donald B. Effler (1915- ), a member of the surgical team that performed the first coronary artery bypass operation F. Mason Sones (1918- ), a physician who developed an improved technique of X-raying the heart’s arteries Fighting Heart Disease In the mid-1960’s, the leading cause of death in the United States was coronary artery disease, claiming nearly 250 deaths per 100,000 people. Because this number was so alarming, much research was being conducted on the heart. Most of the public’s attention was focused on heart transplants performed separately by the famous surgeons Christiaan Barnard and Michael DeBakey. Yet other, less dramatic procedures were being developed and studied. Amajor problem with coronary artery disease, besides the threat of death, is chest pain, or angina. Individuals whose arteries are clogged with fat and cholesterol are frequently unable to deliver enough oxygen to their heart muscles. This may result in angina, which causes enough pain to limit their physical activities. Some of the heart research in the mid-1960’s was an attempt to find a surgical procedure that would eliminate angina in heart patients. The various surgical procedures had varying success rates. In the late 1950’s and early 1960’s, a team of physicians in Cleveland was studying surgical procedures that would eliminate angina. The team was composed of Rene Favaloro, Donald B. Effler, F. Mason Sones, and Laurence Groves. They were working on the concept, proposed by Dr. Arthur M. Vineberg from McGill University in Montreal, of implanting a healthy artery from the chest into the heart. This bypass procedure would provide the heart with another source of blood, resulting in enough oxygen to overcome the angina. Yet Vineberg’s surgery was often ineffective because it was hard to determine exactly where to implant the new artery. New Techniques In order to make Vineberg’s proposed operation successful, better diagnostic tools were needed. This was accomplished by the work of Sones. He developed a diagnostic procedure, called “arteriography,” whereby a catheter was inserted into an artery in the arm, which he ran all the way into the heart. He then injected a dye into the coronary arteries and photographed them with a high-speed motionpicture camera. This provided an image of the heart, which made it easy to determine where the blockages were in the coronary arteries. Using this tool, the team tried several new techniques. First, the surgeons tried to ream out the deposits found in the narrow portion of the artery. They found, however, that this actually reduced blood flow. Second, they tried slitting the length of the blocked area of the artery and suturing a strip of tissue that would increase the diameter of the opening. This was also ineffective because it often resulted in turbulent blood flow. Finally, the team attempted to reroute the flow of blood around the blockage by suturing in other tissue, such as a portion of a vein from the upper leg. This bypass procedure removed that part of the artery that was clogged and replaced it with a clear vessel, thereby restoring blood flow through the artery. This new method was introduced by Favaloro in 1967. In order for Favaloro and other heart surgeons to perform coronary artery surgery successfully, several other medical techniques had to be developed. These included extracorporeal circulation and microsurgical techniques.Extracorporeal circulation is the process of diverting the patient’s blood flow from the heart and into a heart-lung machine. This procedure was developed in 1953 by U.S. surgeon John H. Gibbon, Jr. Since the blood does not flow through the heart, the heart can be temporarily stopped so that the surgeons can isolate the artery and perform the surgery on motionless tissue. Microsurgery is necessary because some of the coronary arteries are less than 1.5 millimeters in diameter. Since these arteries had to be sutured, optical magnification and very delicate and sophisticated surgical tools were required. After performing this surgery on numerous patients, follow-up studieswere able to determine the surgery’s effectiveness. Only then was the value of coronary artery bypass surgery recognized as an effective procedure for reducing angina in heart patients. Consequences According to the American Heart Association, approximately 332,000 bypass surgeries were performed in the United States in 1987, an increase of 48,000 from 1986. These figures show that the work by Favaloro and others has had a major impact on the health of United States citizens. The future outlook is also positive. It has been estimated that five million people had coronary artery disease in 1987. Of this group, an estimated 1.5 million had heart attacks and 500,000 died. Of those living, many experienced angina. Research has developed new surgical procedures and new drugs to help fight coronary artery disease. Yet coronary artery bypass surgery is still a major form of treatment.

28 May 2009

Contact lenses

The invention: Small plastic devices that fit under the eyelids, contact lenses, or “contacts,” frequently replace the more familiar eyeglasses that many people wear to correct vision problems. The people behind the invention: Leonardo da Vinci (1452-1519), an Italian artist and scientist Adolf Eugen Fick (1829-1901), a German glassblower Kevin Tuohy, an American optician Otto Wichterle (1913- ), a Czech chemist William Feinbloom (1904-1985), an American optometrist An Old Idea There are two main types of contact lenses: hard and soft. Both types are made of synthetic polymers (plastics). The basic concept of the contact lens was conceived by Leonardo da Vinci in 1508. He proposed that vision could be improved if small glass ampules filled with water were placed in front of each eye. Nothing came of the idea until glass scleral lenses were invented by the German glassblower Adolf Fick. Fick’s large, heavy lenses covered the pupil of the eye, its colored iris, and part of the sclera (the white of the eye). Fick’s lenses were not useful, since they were painful to wear. In the mid-1930’s, however, plastic scleral lenses were developed by various organizations and people, including the German company I. G. Farben and the American optometrist William Feinbloom. These lenses were light and relatively comfortable; they could be worn for several hours at a time. In 1945, the American optician Kevin Tuohy developed corneal lenses, which covered only the cornea of the eye. Reportedly, Tuohy’s invention was inspired by the fact that his nearsighted wife could not bear scleral lenses but hated to wear eyeglasses. Tuohy’s lenses were hard contact lenses made of rigid plastic, but they were much more comfortable than scleral lenses and could be worn for longer periods of time. Soon after, other people developed soft contact lenses, which cover both the cornea and the iris. At present,many kinds of contact lenses are available. Both hard and soft contact lenses have advantages for particular uses. Eyes, Tears, and Contact Lenses The camera-like human eye automatically focuses itself and adjusts to the prevailing light intensity. In addition, it never runs out of “film” and makes a continuous series of visual images. In the process of seeing, light enters the eye and passes through the clear, dome-shaped cornea, through the hole (the pupil) in the colored iris, and through the clear eye lens, which can change shape by means of muscle contraction. The lens focuses the light, which next passes across the jellylike “vitreous humor” and hits the retina. There, light-sensitive retinal cells send visual images to the optic nerve, which transmits them to the brain for interpretation. Many people have 20/20 (normal) vision, which means that they can clearly see letters on a designated line of a standard eye chart placed 20 feet away. Nearsighted (myopic) people have vision of 20/40 or worse. This means that, 20 feet from the eye chart, they see clearly what people with 20/20 vision can see clearly at a greater distance. Myopia (nearsightedness) is one of the four most common visual defects. The others are hyperopia, astigmatism, and presbyopia. All are called “refractive errors” and are corrected with appropriate eyeglasses or contact lenses. Myopia, which occurs in 30 percent of humans, occurs when the eyeball is too long for the lens’s focusing ability and images of distant objects focus before they reach the retina, causing blurry vision. Hyperopia, or farsightedness, occurs when the eyeballs are too short. In hyperopia, the eye’s lenses cannot focus images of nearby objects by the time those images reach the retina, resulting in blurry vision. A more common condition is astigmatism, in which incorrectly shaped corneas make all objects appear blurred. Finally, presbyopia, part of the aging process, causes the lens of the eye to lose its elasticity. It causes progressive difficulty in seeing nearby objects. In myopic, hyperopic, or astigmatic people, bifocal (two-lens) systems are used to correct presbyopia, whereas monofocal systems are used to correct presbyopia in people whose vision is otherwise normal.Modern contact lenses, which many people prefer to eyeglasses, are used to correct all common eye defects as well as many others not mentioned here. The lenses float on the layer of tears that is made continuously to nourish the eye and keep it moist. They fit under the eyelids and either over the cornea or over both the cornea and the iris, and they correct visual errors by altering the eye’s focal length enough to produce 20/20 vision. In addition to being more attractive than eyeglasses, contact lenses correct visual defects more effectively than eyeglasses can. Some soft contact lenses (all are made of flexible plastics) can be worn almost continuously. Hard lenses are made of more rigid plastic and last longer, though they can usually be worn only for six to nine hours at a time. The choice of hard or soft lenses must be made on an individual basis. The disadvantages of contact lenses include the fact that they must be cleaned frequently to prevent eye irritation. Furthermore, people who do not produce adequate amounts of tears (a condition called “dry eyes”) cannot wear them. Also, arthritis, many allergies, and poor manual dexterity caused by old age or physical problems make many people poor candidates for contact lenses.Impact The invention of Plexiglas hard scleral contact lenses set the stage for the development of the widely used corneal hard lenses by Tuohy. The development of soft contact lenses available to the general public began in Czechoslovakia in the 1960’s. It led to the sale, starting in the 1970’s, of the popular, soft contact lenses pioneered by Otto Wichterle. The Wichterle lenses, which cover both the cornea and the iris, are made of a plastic called HEMA (short for hydroxyethylmethylmethacrylate). These very thin lenses have disadvantages that include the requirement of disinfection between uses, incomplete astigmatism correction, low durability, and the possibility of chemical combination with some medications, which can damage the eyes. Therefore, much research is being carried out to improve them. For this reason, and because of the continued popularity of hard lenses, new kinds of soft and hard lenses are continually coming on the market.